Southwest Mississippi Regional Medical Center began serving the Southwest Mississippi area in 1969; since that time growth has occurred both in the size of the facility and the services provided to patients.

Currently, SMRMC is the health care center for seven Mississippi counties and two Louisiana parishes. One of the newest expansions into health care is the establishment of Family Practice Clinics staffed by nurse practitioners. The Family Practice Clinics are intended to increase the availability and accessibility of primary health care in needed areas, thus meeting the needs of the community.

Each clinic staffs a Family Nurse Practitioners, who in collaboration with a physician, will meet the primary health care needs of all ages in the community. Through the addition of Family Practice Clinics, SMRMC continues to strive to improve the lives of individuals, families, and the community.