Southwest Mississippi Regional Medical Center began serving the Southwest Mississippi area in 1969; since that time growth has occurred both in the size of the facility and the services provided to patients.

Currently, SMRMC is the health care center for seven Mississippi counties and two Louisiana parishes. Through the addition of Family Practice Clinics, Urology Clinic, Neurology Clinic, Internal Medical Clinics, Orthopedic Clinic, and Cardiology Clinic SMRMC continues to strive to improve the lives of individuals, families, and the community.